I'm just an DC noob that read through the wiki but is only on episode 580, but if I were Gosho, considering all that I know has happened, this is what I would do. *pure speculation, no evidence*
In his early days, Anokata worked as a high school detective, and he had a girl he liked, and was childhood friends with: the gaijin girl Vermouth who often helped him with his cases. His father was an important scientist and passed multiple secrets of the trade to Anokata. His father specialized in nuclear warfare, but he dabbled in other things. One day, Anokata years later was in Hiroshima, his hometown with Vermouth when the The bomb came down, and him, his father, and Vermouth, his fiancee. They were all badly poisened with nuclear radiation and in a frantic, panicked moment, Anokata's father pulled out two syringes that contained a experimental version of anti-radition drug. He planned to stick it into his son and himself, Vermouth and Anokata (who were equally panicked) overpowered the father and stuck the syringes into themselves, somehow rendering them into permanent youth. The father, who was dying looked up at them and gave them his blessing before passing away. Anokata felt completely lost because he had killed his own father, and with his strong sense of detective justice he pointed fingers at america and vowed to make them suffer the same fate, unwilling to place the blame on himself. With Vermoth as the legs and him as the brain, he began targeting FBI and CIA agents in an effort to gain information on what really happened back in Hiroshima, and he soon discovered the reason they blew up Hiroshima and Nagasaki was that they were both home to circles of nuclear weapons scientists. After deciding on New York as the target, Vermouth and Anokata temporarily split with Vermouth posing as Sharon and later Chris, and Anokata alternating between New York and Tokyo managing both sides of the plan to blow New York up. They needed a lot of money, and for that reason they set up the Black Organization, recruiting mercenaries and people with their own gruges against America, some of them affectef by Hiroshima and others for different reasons. They perform lots of illegal trades to amass money for the materials for that bomb. They hired the Miyanos, who had been basing a lot of their science off his fathers work, and so in exchange for giving them information from his father's old lab notes, they would make other weapons and basically whatever the organization needed. They took adventage of Itakura, who was developing a mass scale hacking program that would make airplanes be controlled from a distance and allow for even more destruction when the day they would release the bomb came. Vermouth remained a supportive partner through it all, but she too had her doubts because it didn't really matter to her that Anokata's father died, and she question whether it would be okay to blow up a major city of her her home country. Anokata could be, in this sense Araide and was replaced by Vermouth when he was doing business oversees, and the death plan was just a setup to knock the FBI off their trail. Also, normally the FBI and CIA wouldn't care about a Japanese gang, but if they caught wind of nuclear terrorism they would surely send agents. I will close by commenting on a quote from Vermouth. They are not from heaven or hell because the want to kill people in retaliation from being killed. They are bringing back the dead because they are physically manifesting the dead's rage.