In an interview in Singapore in 2016, Gosho confirmed that Akai and Akemi are cousins. It is stated at 34:23 in the audio link. This means that Elena Miyano is Mary's sister, as both are known to be British. (quoted from wiki)
So... assuming that Elena and Mary had been in contact with each other, Mary must also be aware of Elena working for a shady organization. Mary's shrinking could be due to ingesting APTX which was either forced-fed by BO agent (in which case her name should have appeared on the BO's APTX victim list, but not shown so far) or a sample drug of APTX she may have obtained from Elena (to shrink to hide her identity). We are yet to know more about the story of Mary, as she was also rumored to be a MI6 agent.
So if Mary was a MI6 agent, she or her husband may also somehow be involved in the Amanda case (who was involved in sponsoring a shady organization(BO)?) case 17 years ago, which also involved RUM and Amanda's bodyguard Asaca. If the dying message left by Kohji was indeed K(C)arasuma, then how and why did he left that name ? Was Amanda in contact with K(C)arasuma and told him(Kohji) about it, which is why he knew and was aware of that name??? Was Kohji really just a simple chess player who just happened to die due to his implication with Amanda or was he something more?
And... the following may not be so related to this topic, but... I find the information interesting.
"MI6 may be one of the most storied intelligence services but, make no mistake, it is in an existential battle. And the reason for that is data.
The current C, Alex Younger, 52, talks of an "arms race" when it comes to exploiting technology. The intelligence services that succeed in mastering data will prosper against adversaries. Those that fail to adapt will find themselves irrelevant. To avoid that fate, MI6 is trying to answer two questions: what is secrecy in the digital age? And how do you protect it?
Spying involves stealing secrets. There are various ways of doing that...Imagine you want to know if a country is secretly working on a nuclear-weapons programme. The best source might be a businessman in the illicit procurement chain. A spy agency needs to find out who has the access to secrets, the motivation to pass them on and how to get close to that individual. All of that is now data driven.
The data may be open source - publicly available information on who works for a company. Social media can play a role in understanding an individual's interests and connections, building a picture of their lives. Spies say if you want to understand a target you now have to understand the expression of their life online as well as in the physical world - because dissonance between their "real world" and "online" behaviour can be telling."
quoted from : http://www.wired.co.uk/article/spies-da ... don-corera